The enrichment analysis here showed that the DEGs mainly enriched in the muscle filament sliding, myofibril, protein complex, sarcomere, myosin complex, nuclear chromosome, and tight junction. Expression and overall survival analysis of hub genes were performed.Ī total of 15 common DEGs were screened between RMS and normal tissues. Protein-protein interaction network was constructed, and the hub genes was identified by the Cytoscape. Database for Annotation, Visualization and Integrated Discovery and Metascape can perform the enrichment analysis for the DEGs. GEO2R was applied to identify differently expressed genes (DEGs) between RMS and normal group. Gene Expression Omnibus database was used to download the tow gene profiles, GSE28511 and GSE135517. The discovery of biomarker is expected to be the direction of targeted therapy, providing a new direction for the precise treatment of RMS. The discovery of potential postbiomarkers could lead to early and more effective treatment measures to reduce the mortality of RMS. Rhabdomyosarcoma (RMS) is a common malignant soft tissue sarcoma, which is the third most common soft tissue sarcoma after malignant fibrohistoma and liposarcoma. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The authors have no funding and conflicts of interest to disclose.ĭata sharing not applicable to this article as no datasets were generated or analyzed during the current study. 2021 100:39(e27101).Įthical approval was not necessary for this study, as all data were obtained from public databases. ![]() ![]() MYL2 as a potential predictive biomarker for rhabdomyosarcoma. How to cite this article: Wang J, Gao S, Dong K, Guo P, Shan Mj. China (e-mail: ).Ībbreviations: CMYA5 = Cardiomyopathy Associated 5, DAVID = Database for Annotation, Visualization and Integrated Discovery, DEGs = differently expressed genes, GEO = Gene Expression Omnibus, GEPIA = Gene Expression Profiling Interactive Analysis, IGF2 = Insulin Like Growth Factor 2, MYH2 = Myosin Heavy Chain 2, MYL2= Myosin Light Chain 2, PPI = protein-protein interaction, RMS = rhabdomyosarcoma, TOP2A = DNA Topoisomerase II Alpha. 429 Beihuan Road, Fuyang District, Hangzhou 311499, P.R. ∗Correspondence: Junning Wang, The second Department of orthopedics, Hangzhou Fuyang District First People's Hospital, No. 9 Dongdansantiao, Dongcheng District, Beijing 100730, ChinaĮDepartment of plastic surgery, Peking Union Medical College Hospital, Beijing, 100730, China. ChinaĭGraduate School, Chinese Academy of Medical Sciences & Peking Union Medical College, No. ChinaīBethune Second Clinical Medical College of Jilin University, 218Ziqiang Hutong, Nanguan District, Changchun City, Jilin Province 130041, ChinaĬSchool of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei 050017, P.R. ![]() I can fix the issue from the “Fix It” option.AThe second Department of orthopedics, Hangzhou Fuyang District First People's Hospital, No. In our example, I’ve some issue with RMS requirement Once installed the RMS analyze tool we can perform few actions and first we start with the Azure RMS User Restores the RMS client to the default state.Installs missing Azure RMS prerequisites.The RMS analyze tool can perform remediation on the client machine with the following actions: Azure RMS prerequisites (required hotfixes, registry key settings, Microsoft Online Sign-in Assistant, etc.). ![]() Azure RMS certification, licensing, and pre-licensing functionality.Office 2010, 2013, and 2016 registry settings.The RMS Diagnostic tests that check the following settings: The RMS Analyzer can be used to check the settings, configuration, and health of your Azure RMS infrastructure and the client applications that use RMS. In the next series of articles, we will understand how to troubleshoot and resolve common and special issues that can occur when working with Azure Information Protection.Īzure RMS Analyzer Tool is a small but useful tool that can help you in solving your problem by analyzing your work against the Azure AIP service.
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